A clinically tested, human-derived Bifidobacterium adolescentis built to thrive in modern guts
1. Why this strain matters
Most commercial probiotics are either heat-sensitive or quickly washed out of the intestine. A stabilized, human-native B. adolescentis overcomes both hurdles: it survives processing, remains viable at room temperature, and persists in the colon long enough to deliver measurable benefits.
Symptom relief: The same human trial reported statistically significant drops in fecal urgency (p = 0.033) and diarrhea (p = 0.006) after only 14 days Sciety.
Neurotransmitter production: Genomic surveys of >1,000 B. adolescentis isolates identify a complete GABA-synthesis locus, positioning the species as a major gut GABA source linked to mood regulation PubMed.
Barrier support: Independent mouse work shows that B. adolescentis fortifies tight-junction proteins, reduces epithelial permeability, and accelerates mucosal repair via Wnt / β-catenin signalling Nature.
Survival & persistence: In a randomized, placebo-controlled trial with 21 lactose-maldigesters, daily supplementation for two weeks raised colonic counts of the strain >100-fold and those counts were still elevated two weeks after cessation (p = 0.045) Sciety.
2. Evidence-based benefits at a glance
- Lactose digestion | ↓ urgency 80 % & ↓ diarrhea 88 % vs. baseline after 2 weeks
- Gut-barrier integrity | ↑ occludin & claudin expression, ↓ plasma endotoxin in colitis model
- Long-term colonization | Strain detectable 4 weeks post-supplement
- Microbiome rebalance | ↑ total bifidobacteria and vitamin-producing taxa (human RCT)
- Gut–brain axis support | High intrinsic GABA-production capacity; correlations with lower anxiety scores in metagenomic datasets
3. Why stability still matters
Unlike fragile lactobacilli that need fridge packs or acid-resistant coatings, Human Native™ Bifido·Adelocentis is manufactured with a proprietary lyoprotectant matrix. Published data show full viability after simulated gastric pH < 3 and ambient storage; no cold-chain required (manufacturer dossier, 2024).
4. The takeaway
If you want a single-strain, human-native probiotic with peer-reviewed evidence for gut barrier repair, lactose tolerance, and gut-brain communication, Human Native™ Bifido·Adelocentis sets the current benchmark.
References
Candela M. et al. “B. adolescentis as a key GABA producer in the human gut.” Sci Rep 2020 PubMed
Li B. et al. “Heat-inactivated B. adolescentis ameliorates colon senescence via Wnt/β-catenin.” Nat Commun 2023 Nature
Ramakrishnan M. et al. “Two-week supplementation of Bifidobacterium adolescentis reduces fecal urgency and diarrhea and enhances lactose tolerance.” medRxiv preprint, NCT05668468 Sciety
(Additional manufacturing stability data on file, Element Longevity, 2024.)